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16年专注胆汁酸对脂肪利用和肝肠健康的研究

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高剂量胆汁酸对肉鸡生长性能、临床血液代谢物及器官发育的影响

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浏览:- 发布日期:2019-08-12 17:14:22【

Bile acids are intended for use in animal feed as a novel feed additive to enhance fat absorption. As far as we know, few studies in avian species have been reported, and a safety study of bile acids has not been done. Therefore, a subchronic broiler chicken safety study was conducted to evaluate whether or not high-dose bile acids could affect the health of broiler chickens. A total of 324 1-day-old Arbor Acres broiler chickens were randomly assigned to 3 treatments with 6 replicates of 18 broiler chickens each. Broiler chickens were fed a corn-soybean meal diet supplemented with 0, 80 (the recommended available dose, RAD), and 400 mg/kg (5-fold of RAD) of bile acids for 42d, respectively. Throughout the study, clinical observation and growth performance were measured. At the end of the study, broiler chickens were subjected to a full postmortem examination: blood samples were collected for clinical pathology, selected organs were weighed, and specified tissues were taken for subsequent histopathological examination. No treatment-related changes considered to be of toxicological significance were observed. Therefore, a nominal bile acids inclusion of 400mg/kg was considered to be the no-observed adverse-effect level.

Key words:broiler chickens, bile acids, safety evaluation, blood parameters, organ development

摘 要:作为一种新型的饲料添加剂,胆汁酸被广泛应用于饲料中促进脂肪的吸收利用。目前为止,胆汁酸在家禽上的研究报道很少,其安全性也未进行过研究。因此,我们以肉仔鸡为研究对象,开展亚慢性安全性研究,以评估高剂量胆汁酸是否会影响其健康。将324只1日龄AA肉鸡随机分为3个处理,每个处理6个重复,每个重复18只。肉鸡饲喂玉米-豆粕饲料,分别添加0、80(推荐有效剂量,RAD)和400 mg/kg(5倍推荐有效剂量)胆汁酸,试验期42天。试验过程中,对临床观察和生长性能进行测定。试验结束时,屠宰后,对肉鸡进行全面的检验:采集血液样品用来进行临床病理检验;对选定的器官称重;采集特定组织的样品用来进一步进行组织病理学检查。没有观察到与试验处理相关的、具有毒理学意义的异样。因此,胆汁酸添加水平为400 mg/kg时,是不会出现副作用的添加水平。

关键词:肉仔鸡;胆汁酸;安全评价;血液指标;器官发育

全文要点:

1、肉鸡日粮中添加80 mg/kg胆汁酸,能显著提高末重和日增重,降低料重比;

2、肉鸡日粮中添加80 mg/kg胆汁酸,能显著降低血清中谷丙转氨酶(ALT)和谷草转氨酶(AST)活性,改善肝脏健康;

3、实验结束时血糖浓度明显下降,说明高剂量的胆汁酸具有潜在的降糖作用。

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