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16年专注胆汁酸对脂肪利用和肝肠健康的研究

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日粮中不同能量和胆汁酸水平对肉鸡生长性能和脂质代谢的影响

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浏览:- 发布日期:2019-08-19 15:00:46【

Effects of diets with different energy and bile acids levels on growth performance and lipid metabolism in broilers

This experiment was conducted to evaluate the effects of bile acids (BAs) on the growth performance and lipid metabolism of broilers fed with different energy level diets. 480 one-day-old Arbor Acres broilers (45.01 ± 0.26 g) were allotted to a 2 × 2 factorial design with 2 levels of energy (basal or high-energy level) and 2 levels of BAs (with or without BAs supplementation), resulting in 4 groups of 8 replicates; the experiment lasted 42d. High-energy diets decreased the feed/gain ratio (F/G) from 1 to 21d (P < 0.05), and increased the liver index and abdominal fat percentage at 42d (P < 0.05). The serum total triglyceride (TG) and high-density lipoprotein cholesterol at 42 d were increased by high-energy diets (P<0.05), while the hepatic lipoprotein lipase (LPL) activity at 21 and 42d was decreased (P< 0.05). BAs supplementation increased the body weight at 21d and decreased the F/G during entire period (P < 0.05), as well as improved the carcass quality reflected by decreased abdominal fat percentage at 42d and increased breast muscle percentage at 21 and 42d (P < 0.05). The serum TG at 21 and 42d were decreased by BAs (P < 0.05), and the hepatic LPL activity at 42d was increased (P < 0.05). In addition, high-energy diets increased the expression of sterol regulatory element binding transcriptio factor 1, acetyl-CoA carboxylase, and fatty acid synthase (P < 0.05), while BAs diets decreased these genes expression (P < 0.05). Moreover, BAs supplementation also increased the expression of carnitine palmitoyltransferase 1 (P < 0.05), which was increased in high-energy groups (P < 0.05). In conclusion, BAs supplementation could increase growth performance, elevate carcass quality, and improve lipid metabolism in broilers.

Key words:  bile acids, broiler, energy, growth performance, lipid metabolism

日粮中不同能量和胆汁酸水平对肉鸡生长性能和脂质代谢的影响

摘 要:本实验旨在研究胆汁酸(BAs)日粮中不同能量水平下添加胆汁酸对肉鸡生长性能和脂质代谢的影响。480只1日龄AA肉鸡(45.01±0.26 g)采用2×2因子设计,两个能量水平(基础组和高能组),两个胆汁酸梯度(添加组和不添加)组,试验分为4组,每组8个重复,试验期42 d。高能组21 d时料肉比显著降低(P<0.05), 42 d时肝脏指数和腹脂率显著增加(P<0.05)。高能组42 d血清总甘油三酯(TG)、高密度脂蛋白胆固醇含量显著升高(P<0.05),而21 d和42 d肝脂蛋白酯酶(LPL)活性显著降低(P<0.05)。添加BA可显著提高21 d体重,降低全程料肉比(P<0.05),并显著改善42 d胴体品质,表现为腹脂率显著降低,21 d和42 d胸肌率显著增加(P<0.05)。添加BA可显著降低21 d和42 d血清甘油三酯(TG)含量,提高42 d肝脂蛋白酯酶活性(P<0.05)。此外,高能组固醇响应元件结合转录因子1、乙酰辅酶A羧化酶、脂肪酸合成酶的表达显著提高(P<0.05),而添加BA则显著降低了这些基因的表达(P<0.05)。另外,添加BAs还能显著提高肉碱棕榈酰转移酶1的表达(P<0.05),其在高能组显著提高(P<0.05)。综上所述,添加BA可以提高肉鸡生长性能,改善胴体品质,促进脂质代谢。

关键词:  胆汁酸;肉鸡;能量;生长性能;脂质代谢

全文要点:

1、胆汁酸可显著提高日增重,降低料重比;

2、胆汁酸可提高胸肌率1.4%,显著降低42 d高能组肝脏指数、腹脂率,表明胆汁酸能使用更多的营养物质促进肌肉生长而不是脂肪沉积;

3、胆汁酸可提高血清肝脂蛋白酯酶(血清总甘油三酯水解成脂肪酸的限速酶)的活性,降低血清脂肪酸水平,从而降低肝脏或腹部脂肪的沉积;

4、胆汁酸能够激活FXR受体。通过抑制SREBF1/FAS/ACC(脂肪合成基因)表达,从而抑制脂肪生成;胆汁酸能够提高CPT1/PPARα(脂肪代谢基因)表达。最终,胆汁酸通过调节脂质代谢相关基因的表达,促进脂肪分解,抑制脂肪合成,减少脂肪沉积。

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